The Mighty Healer worked so incessantly, so intensely,—and often without food,—that some of His friends feared He could not much longer endure the constant strain. His brothers heard of this, and also of the charge brought by the Pharisees that He cast out devils through the power of Satan. They felt keenly the reproach that came upon them through their relation to Jesus. They decided that He must be persuaded or constrained to cease His manner of labor, and they induced Mary to unite with them, thinking that through His love for her they might prevail upon Him to be more prudent. CH 526.2
Jesus was teaching the people when His disciples brought the message that His mother and His brothers were without and desired to see Him. He knew what was in their hearts, and “He answered and said unto him that told Him, Who is My mother? and who are My brethren? And He stretched forth His hand toward His disciples, and said, Behold My mother and My brethren! For whosoever shall do the will of My Father which is in heaven, the same is My brother, and sister, and mother.” Matthew 12:48-50. CH 526.3
The enmity kindled in the human heart against the gospel was keenly felt by the Son of God, and it was most painful to Him in His home; for His own heart was full of kindness and love, and He appreciated tender regard in the family relation. But with their short measuring line His brothers could not fathom the mission that He came to fulfill and therefore could not sympathize with Him in His trials. CH 527.1